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Unopposed Cathepsin G, Neutrophil Elastase, and Proteinase 3 ...
This epidemic disease is expected to rank as the third cause of mortality in the coming years. ... According to the protease-antiprotease hypothesis, smoking evokes ... Protease activities were tested using elastin zymography or kinetic ... .. protected the host from the lung tissue destruction associated with CS ... .. |
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Cleavage of CXCR1 on neutrophils disables bacterial killing in ...
Unopposed proteolytic activity in the airways of individuals with ... . Figure 2: CXCR1 expression on airway neutrophils is associated ... .. fibrosis lung disease was corroborated by the effects of antiprotease treatment in vivo. |
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Antiprotease | definition of antiprotease by Medical dictionary
Looking for online definition of antiprotease in the Medical Dictionary? ... Antiprotease activity could therefore be a useful property of a drug because it could prevent ... New understanding of drug action in Alzheimer's disease could help develop more ... The consequence of the latter, unopposed by an effective antiprotease ... |
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Inflammation in cystic fibrosis lung disease: Pathogenesis and therapy
Although CF lung disease is primarily an infectious disorder, the associated ... Keywords: Lung inflammation, Cystic fibrosis, Neutrophils, Anti-inflammatory therapies, ... .. To prevent harmful free proteolytic activities, all serine proteases are tightly ... Based on these protease-driven disease concepts, neutralizing unopposed ... |
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Inhibition of airway proteases in cystic fibrosis lung disease...
The local protease–antiprotease imbalance in CF airway fluids has been ... not due to an intrinsic CFTR-associated lack of antiproteases since CF patients ... Accordingly, HLE was responsible for 90% of the activity, protease 3 for 7% and ... . Taken together, unopposed HLE is able to undermine several key ... |
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Antiproteases as Therapeutics to Target Inflammation in Cystic ...
Antiprotease strategies to dampen the excessive inflammatory response and ... The main source of protease activity in the CF lung is thought to be activated ... .. of lung diseases are characterised by the presence of multiple unopposed protease ... . the lung, was shown to activate the granule-associated serine proteases NE, ... |
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Pathogenic Mechanisms in Emphysema: From Protease Anti...
severely deficient AAT levels leading to proteolytic activity and the development of ... antiprotease deficiency to lead to unopposed proteolysis in the lung. ... with bronchitis or other lung diseases (Muley et al., 1994). ... . activator inhibitor type 1) , were associated with COPD in a Boston population study ( ... . |
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Quantification and Evaluation of the Role of Antielastin ...
Chronic obstructive pulmonary disease (COPD) may be an autoimmune disease. ... (Z-A1ATD) and cystic fibrosis (CF) are associated with impaired pulmonary antiprotease defences leading to unopposed protease activity. |